However, published data vary regarding the accuracy of ultrasound in the diagnosis of cervical lymph node metastasis. The high diagnostic accuracy of multidetector ct shown in this metaanalysis and in several other reports supports the switch from catheter angiography to multidetector ct as the firstline imaging. Combining independent studies of a diagnostic test into a summary roc curve. Optical coherence tomography oct is an emergent imaging tool used for noninvasive diagnosis of skin diseases. Diagnostic and grading accuracy of 18 ffdopa pet and petct. When more than one study reported a variable, we pooled the data using meta. Six electronic databases, pubmedmedline, embase, cochrane library, cnki, vip data, and wanfang data, were utilized to retrieve articles praising the diagnostic value of 3d shoulder us for use in detecting rotator cuff tears. Metadisc is a freeware software developed by a group of statisticians in spain to perform metaanalysis of diagnostic and screening tests. Circulatory metastinkisspeptin1 in polycystic ovary.
A metaanalysis of use of prostate imaging reporting and data. Our own metaanalysis also attempted to partially account for the variability observed, analyzing the role of several moderator variables. Diagnostic accuracy of history, physical examination. The deliskaplan executive function system sorting test as an evaluative tool for executive functions after severe traumatic brain injury. First, the number of included studies and the overall sample size in our metaanalysis are larger. Aki criteria were performed as moderators in the meta regression analyses to explore possible sources of heterogeneity. I have used first meta disc, but only for descriptive purposes, as it is clear that univariate approaches such as those provided by this package are biased eg takwoingi et al. I am conducting a meta analysis of diagnostic test accuracy studies focusing on myocardial perfusion imaging. Ai is a science that applies intelligent machines and systems to imitate the ability of intelligent human activities.
Metadisc has a graphical user interface with rolldown menus, dialog boxes, and online help facilities. It used to be available for download from the groups website, and now the new version metadisc 2. Pax1 and sox1 methylation as an initial screening method for. Metadisc allows users to test for heterogeneity amongst various studies in two different ways. A previous meta analysis on screening tests for osa17 was published in 2000 and described the analysis of several screening methods, including partial time polysomnography, partial channel polysomnography, oximetry, portable devices, prediction equations, flowvolume loops, global impression, questionnaires, and other clinical, chemical, and. We conducted this study according to the recommendations of the cochrane collaboration diagnostic test accuracy working group. Engauge digitizer and stata software were applied for prognostic data extraction and analysis. A meta analysis was published in 2018, which assessed the diagnostic performance of optical coherence tomography to detect bladder cancer. Metaanalyses of diagnostic accuracy in imaging journals rsna. Pdf zamora j, abraira v, muriel a, khan k, coomarasamy. Assessing methylation status of pax1 in cervical scrapings, as a novel diagnostic and predictive biomarker, was closely related to screen cervical cancer. Last but not least, metadisc provides a bunch of analyses, but not all of them are suitable for metaanalysis of test accuracy. Finally, since most studies included in our analysis were published before the who 2016 classification system. If the studies are reasonably homogeneous, the accuracy estimates from individual studies will lie along a line corresponding to the pooled accuracy estimate.
Zamora j, abraira v, muriel a, khan ks, coomarasamy a. Clinical epidemiology program, ottawa hospital research. Accuracy of susceptibilityweighted imaging and dynamic. A metaanalysis of the diagnostic accuracy of the scoff. In this article, we present meta disc, a windowsbased, userfriendly, freely available for academic use software that we have developed, piloted, and. Data analysis was performed using the metadisc statistical software version 1. With predefined inclusion criteria, eligible studies were included, followed by quality assessment using the quality assessment of diagnostic accuracy studies scoring system. Then, i have found the following bivariate methods, and. The program has been developed by the unit of clinical biostatistics team of the ramon y cajal hospital in madrid spain. Doaj is an online directory that indexes and provides access to quality open access, peer. Accuracy of ultrasound for the diagnosis of cervical lymph. Diagnostic and prognostic value of circulating tumor dna in. Metaanalysis of clinical studies of diagnostic tests. A metaanalysis of use of prostate imaging reporting and.
Jul 12, 2006 all computational algorithms have been validated through comparison with different statistical tools and published meta analyses. First, the number of included studies and the overall sample size in our meta analysis are larger. We performed a meta analysis to obtain the diagnostic and grading accuracy of 18ffdopa pet and petct in patients with gliomas. Pubmed, embase, cochrane library and web of science databases were searched for relating literature published up until november 30, 2016. In this article, we present metadisc, a windowsbased, userfriendly, freely available for academic use software. Diagnostic accuracy of rating scales for attentiondeficit. Nineteen positive and negative lrs were calculated from 8 studies of 8 ef measures. These previously mentioned processes of statistical analysis were conducted with metadisc statistical software version 1. Conclusion metadisc is a comprehensive and dedicated test accuracy metaanalysis software. We performed a meta analysis to assess the efficacy of ultrasound for detecting cervical lymph node metastasis in patients with esophageal cancer. Pdf diagnostic and prognostic value of circulating tumor. It has already been used and cited in several metaanalyses published in highranking journals. Meta disc is free for all users and easy to learn and use. Metaanalysis to compare the accuracy of genexpert, mods.
Accuracy of realtime shear wave elastography in staging. I am conducting a metaanalysis of diagnostic test accuracy studies focusing on myocardial perfusion imaging. However, there is currently no dedicated and comprehensive software for metaanalysis of diagnostic data. This pooled analysis aims at evaluating the diagnostic accuracy of circulating tumor ct dna for the detection of egfrt790m mutation in nsclc patients who progressed after egfrtkis. Diagnostic and grading accuracy of 18 ffdopa pet and pet. Sas is short for its previous name statistical analysis.
A comprehensive literature search of electronic databases was performed by two observers independently. Only two studies reported all data for diagnostic accuracy. It can be used as an adjunct test in a combination algorithmic approach. In this study, the results of meta analysis were carried out and indicated that the 68ga pet or petct had higher accuracy in diagnosis of nets, with a pooled sensitivity and specificity of 90. All analyses were conducted by meta disc version 1. The diagnostic performance of the test was high with an area under the curve of auc 0. The name of the package stands for bayesian metaanalysis of diagnostic test data. Metaanalysis of diagnostic accuracy of neutrophil cd64. Effectiveness of 3dimensional shoulder ultrasound in the di. Who has previously recommended sputumsmear examination at the end of the second month of treatment in patients with recently diagnosed pulmonary tuberculosis, and, if positive, extension of the intensive therapy phase. Diagnostic accuracy variables were pooled by the meta disc software. Prediction of poor outcome after hypoxicischemic brain. If heterogeneity due to threshold effect were present, the accuracy data can be pooled by fitting a sroc curve and summarising that curve by means of the auc. A metaanalysis evaluating the accuracy of colon capsule endoscopy in detecting colon polyps.
Zamora j, abraira v, muriel a, khan k, coomarasamy a. All computational algorithms in it have been validated through comparison with different statistical tools and published metaanalyses. Accuracy of p57kip2 compared with genotyping to diagnose. Unlike other dedicated metaanalysis packages, metaanalyst integrates the capabilities to perform metaanalyses of binary or continuous outcomes and diagnostic or prognostic tests, combining the functionality of software. This metaanalysis showed that the diagnostic performance of ncd64 for neonatal sepsis was not good, because the pooled sensitivity and specificity are not high enough. In this study, the results of metaanalysis were carried out and indicated that the 68ga pet or petct had higher accuracy in diagnosis of nets, with a pooled sensitivity and specificity of 90. Last but not least, meta disc provides a bunch of analyses, but not all of them are suitable for meta analysis of test accuracy studies. Metaanalysis of diagnostic and screening test accuracy evaluations. Next, we conducted a comprehensive meta analysis using the meta disc and several complementary techniques. Statistical analyses were conducted using the software metadisc version 1. Diagnostic accuracy of efast in the trauma patient. To this end, we searched the pubmed, embase, and cochrane library databases for studies that examine the diagnostic accuracy of dwi in predicting hibi outcomes in adult patients between january1995 and september 2019. A sensitivity analysis was done to exclude patients with a uti.
Sputum monitoring during tuberculosis treatment for. In recent years, the role of cta and ctp for vasospasm diagnosis in the setting of asah has been the subject of many research studies. Zamora j, abraira v, muriel a, khan k, coomarasamy ameta disc. Accuracy of 18fflurodeoxyglucosepositron emission tomography. The present meta analysis was carried out to assess the accuracy of oct for the diagnosis of skin cancer. Second, we used a bivariate model to pool the diagnostic accuracy of he4 while the previous study used a randomeffects model with the metadisc software. Second, we used a bivariate model to pool the diagnostic accuracy of he4 while the previous study used a randomeffects model with the meta disc software version 1. Neutrophiltolymphocyte ratio as a biomarker for predicting. A meta analysis evaluating the accuracy of colon capsule endoscopy in detecting colon polyps. Purpose to describe quality indicators for appraising studies of diagnostic accuracy and to report a metaanalysis of measures for diagnosing language impairment li in bilingual spanishenglish u. Metaanalysis is a twostage process involving the estimation of an appropriate summary statistic for each of a set of studies, followed by the. Positron emission tomography pet and petcomputed tomography petct imaging with 3,4dihydroxy618f fluorolphenylalanine 18ffdopa has been used in the evaluation of gliomas. We extracted data on the study design, population, sample size, and the data used to calculate test characteristics true positives, false positives, false negatives, and true negatives. Optical coherence tomography for the diagnosis of malignant.
Inclusion criteria were original research using the pirads v2 system in reporting prostate mri. This list is generated based on data provided by crossref. I have used first metadisc, but only for descriptive purposes, as it is clear that univariate. Apr, 2011 metaanalysis is a statistical technique used to derive an aggregate result from a series of studies that address a particular research question. Metadisc is a comprehensive and dedicated test accuracy metaanalysis software. Metadisc provides a bunch of analyses, but not all of them are suitable for metaanalysis of test accuracy studies. When performing a metaanalysis of diagnostic accuracy, authors usually need to use. Recommended softwarepackages for metaanalysis of diagnostic. All analyses were performed using the software meta. Magnetocardiography for the diagnosis of coronary artery. Nitrate reductase assay for rapid detection of isoniazid.
A metaanalysis of clinical screening tests for obstructive. Which is the best method for metaanalysis of diagnostic test. Metadisc is freeware software to perform metaanalysis of studies of evaluations of diagnostic and screening tests. Pubmed, embase, cochrane library and web of science were searched through may.
A metaanalysis evaluating the accuracy of colon capsule. In studies in which receiver operator characteristic roc data were presented, the dta meta analysis was conducted to obtain summary roc curve sroc with pooled sensitivity, specificity and diagnostic odds ratio dor of kiss1 for pcos. Diagnostic accuracy of optical coherence tomography for. Sensitivity, specificity, likelihood ratio lr and diagnostic odds ratio dor were used as measures of the diagnostic accuracy. It has already been used and cited in several metaanalyses. Magnetic resonance imaging on disease reclassification among. A close association between kisspeptin1 kiss1 and reproductive physiology has been reported, but the results on circulatory kiss1 are ambiguous in patients with polycystic ovary syndrome pcos. Overall metadisc is free for all users and easy to learn and use. Unlike other dedicated meta analysis packages, meta analyst integrates the capabilities to perform meta analyses of binary or continuous outcomes and diagnostic or prognostic tests, combining the functionality of software such as mix and meta disc.
Data from primary studies, including study id, accuracy. Metaanalytic summaries are needed on clinical studies of diagnostic tests. Diagnostic accuracy of human epididymis secretory protein. Accuracy of computed tomographic enterography for obscure. The diagnostic accuracy of artificial intelligence in thorac.
After screening and diluting out the articles that met inclusion criteria to be used for statistical analysis, the pooled evaluation indexes including. The quadas2 includes 4 parts regarding patient selection, index test, reference. Data was extracted by one author and verified by another author for accuracy. However, there is currently no dedicated and comprehensive software for meta analysis of diagnostic data. Methods a systematic literature search was performed to locate all publications reporting on the diagnostic accuracy. The metadisc software was used to implement the metaanalysis, and sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio with their 95% confidence intervals cis were used as the effect size. Sas is short for its previous name statistical analysis system. Pdf recommended softwarepackages for metaanalysis of. May 19, 2015 active surveillance as is an increasingly important attempt to avoid overtreatment of patients who harbor clinically insignificant disease while offering curative treatment to those in whom.
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